This table provides information on the status of harmonization or standardization of measurands. Additional information regarding the medical impact and harmonization status is available by clicking on the measurand name. The harmonization status shown in the table reflects the situation in economically well developed countries and other geographic areas when measurement procedures supplied by global IVD manufactures are used. The harmonization status may be different when reagents, calibrators and instruments from other suppliers are used.

The medical impact of harmonization, or priority for harmonization, is based on the influence of non-harmonized results on potential medical errors when interpreting a result for a measurand.

Harmonization status:

  • Active means an organization is implementing a harmonization project.
  • Adequate/Maintain means the current harmonization is suitable for medical decisions and existing reference systems must be maintained to ensure the status remains adequate.
  • Inactive means a harmonization activity was started, is no longer being actively implemented but should be reinstated.
  • Incomplete means resources to achieve harmonization are available but have not been adequately implemented.
  • Needed means no harmonization activity has been started but one is needed.

The Resources column notes when information on reference materials, reference measurement procedures, and reference laboratory services are listed by JCTLM.

The Organization column provides information on organizations actively addressing harmonization or standardization for the measurand, or developing reference materials or reference measurement procedures for the measurand.

Comments on measurand status can be sent using the Contact Us tab. Download the form to submit a new measurand.

Summary of Measurand Harmonization Activities

The measurand table is a dynamic information resource. Check regularly for new information.

Click on a measurand to see additional information regarding harmonization status and medical impact.

Click on a link (blue text) for information on a resource or organization.

Click on a single column to sort the table.

Measurand Matrix Medical Impact of Harmonization Harmonization Status Resources Organization
Alanine Aminotransferase (ALT) Serum Medium Incomplete JCTLM
Albumin Serum Medium Needed JCTLM
Albumin Urine High Active   NKDEP
Alkaline Phosphatase (ALP) Serum Medium Incomplete JCTLM
Alpha Fetoprotein Serum High Adequate/Maintain    
Amylase Serum Low Active JCTLM
Anti-DNA antibody (qualitative) Serum Low    
Anti-DNA antibody (quantitative) Serum Medium Needed    
Anti-HBs Qualitative Serum, Plasma High Adequate/Maintain    
Anti-HBs Quantitative Serum, Plasma Medium Needed    
Anti-Hepatitis B core (Anti-HBc total IgM and IgG) Serum, plasma High Adequate/Maintain    
Anti-Hepatitis B Surface Antigen (Anti-HBsAg) Serum, Heparin Plasma High Needed WHO
Anti-Hepatitis C Virus antibody (Anti-HCV Ab) Serum Medium Adequate/Maintain    
Anti-myeloperoxidase (MPO) antibody, IgG Serum High Needed JCTLM
Anti-SSA antibody IgG Serum Medium Needed    
Antinuclear antibody (ANA) fixed cells or serum Active   International Workshops and Consensus Conferences
Antistreptolysin O Serum Low Needed    
Aspartate Aminotransferase (AST) Serum Medium Incomplete JCTLM
B-type Natriuretic Peptide (BNP) Serum High Needed    
BCR-ABL1 Whole blood, bone marrow High Adequate/Maintain JCTLM
Bilirubin, conjugated Serum Medium Needed    
Bilirubin, total Serum High Adequate/Maintain JCTLM
Blood gasses (pH, pO2, pCO2, oximitry) Blood High Adequate/Maintain    
C-Peptide Serum Medium Active JCTLM
University of Missouri
National Metrology Institute of China
C-Reactive protein, high sensitivity Serum Medium Adequate/Maintain    
C-Reactive protein, inflammatory Serum Low Incomplete JCTLM
CA 125 Serum High Needed    
CA 15-3 Serum High Needed    
CA 19-9 Serum High Needed    
Calcium Serum High Adequate/Maintain JCTLM
Calcium, ionized Blood Medium Needed    
Carbamazepine Serum Medium Adequate/Maintain JCTLM
Carbohydrate-deficient transferin (CDT) Serum Medium Active JCTLM
Carboxyhemoglobin Blood Medium Adequate/Maintain    
Carcinoembrionic antigen (CEA) Serum High Needed    
Chlamydia Trachomatis PCR Urine, Vaginal Swab High Adequate/Maintain    
Chloride Serum High Adequate/Maintain JCTLM
Cholesterol, HDL Serum High Incomplete JCTLM
Cholesterol, LDL Serum Medium Incomplete JCTLM
Cholesterol, total Serum High Adequate/Maintain JCTLM
CO2, Total Serum, Heparin Plasma Medium Needed    
Complement Total (CH50) Serum Medium Needed    
Compliment C3 Serum Medium Active JCTLM
Compliment C4 Serum Medium Active JCTLM
Cortisol Serum Medium Incomplete JCTLM
Creatine Kinase (CK) Serum Medium Incomplete JCTLM
Creatinine Serum High Adequate/Maintain JCTLM
CSF Proteins CSF Medium Active   IFCC
Cyclosporin Blood High Active   IFCC Working Group on Immunosuppressive Drugs
Cytomegalovirus (CMV) Plasma Medium Needed    
Cytomegalovirus IgG (CMV IgG) Serum Medium Adequate/Maintain    
D-dimer plasma High Needed    
Digoxin Serum Medium Needed JCTLM
Elastase I Fecal, Serum Low Unknown    
Epstein-Barr Virus Blood Medium Active   National Cancer Institute, NIH, USA
Estradiol (17-beta) Serum High Active JCTLM
Ethyl Alcohol Serum, Plasma Medium Adequate/Maintain JCTLM
Ferritin Serum, Plasma Medium Adequate/Maintain    
Fetal fibronectin Cervical fluid Low Unknown    
Fibrin Degradation Products (D-dimer) plasma High Needed    
Folate Serum Medium Needed WHO IS 03/178
Fructosamine Serum Low Adequate/Maintain    
Gamma glutamyl transferase (GGT) Serum Medium Adequate/Maintain JCTLM
Gentamicin Serum/plasma Medium Adequate/Maintain JCTLM
Glucose Serum High Adequate/Maintain JCTLM
Glucose Urine Low Adequate/Maintain JCTLM CRM
Glucose (POCT) Blood High Adequate/Maintain JCTLM
Glycated Albumin Serum Medium Adequate/Maintain    
Growth Hormone Serum High Active IFCC
Hematocrit Blood High Adequate/Maintain   ICSH
Hemoglobin Blood High Adequate/Maintain JCTLM as haemiglobincyanide
International Council for Standardization in Haematology
Hemoglobin A1c (HbA1c) Blood High Adequate/Maintain JCTLM
Hemoglobin A2 (HbA2) Serum Medium Active   IFCC
Hemoglobin, fetal (HbF) Blood Low Adequate/Maintain    
Hepatitis B Surface Antigen (HBsAg) Serum, Heparin Plasma High Adequate/Maintain WHO
Hepatitis C Ab qualitative Serum, Plasma High Adequate/Maintain    
Hepatitis C Virus RNA Serum High Adequate/Maintain    
HIV-1 Genotype Plasma, Dried blood spots High Adequate/Maintain    
HIV-RNA Serum, Plasma High Adequate/Maintain    
Human Chorionic Gonadotropin (hCG) Serum High Needed    
IgA, total Serum Medium Adequate/Maintain JCTLM
IgE, total Serum Medium Adequate/Maintain    
IgG, Total Serum Medium Adequate/Maintain JCTLM
IgM, total Serum Medium Adequate/Maintain JCTLM
Insulin Serum Medium Active   IFCC
Iron Serum Medium Adequate/Maintain    
Iron Binding Capacity (Total): TIBC Serum Low Adequate/Maintain    
Iron binding capacity (unsaturated ) Serum Low Adequate/Maintain    
Iron saturation Serum Low Adequate/Maintain    
Lactate Serum High Adequate/Maintain    
Lactate Dehydrogenase (LDH) Serum Medium Incomplete JCTLM
Lipase Serum Medium Active   IFCC
Lithium Serum, Heparin Plasma High Adequate/Maintain JCTLM
Lp (a) serum/ plasma High Active   IFCC
Magnesium Serum High Adequate/Maintain JCTLM
Methemoglobin Blood Low Inactive    
Methotrexate Serum Low Adequate    
Myoglobin Serum, Urine Low Adequate/Maintain    
Neisseria gonorrhea DNA by PCR Urine, Vaginal Swab High Adequate/Maintain    
Osmolality Serum Medium Adequate/Maintain    
Osmolality Urine Medium Adequate/Maintain    
Oxyhemoglobin Blood Medium Adequate/Maintain    
Pancreatic lipase Serum Medium Active   IFCC
Parathyroid hormone (PTH) Serum High Active   IFCC
Phenobarbital Serum, Plasma Medium Adequate/Maintain JCTLM
Phenytoin Serum Medium Adequate/Maintain JCTLM
Phosphate Serum Medium Adequate/Maintain    
Platelet Count Blood High Needed JCTLM
Potassium Serum High Adequate/Maintain JCTLM
Pregnancy-Associated Plasma Protein A Plasma Active   IFCC
Procalcitonin Serum High Needed    
Prostate Specific Antigen (PSA) Serum High Needed JCTLM
Protein in CSF CSF Low Active   IFCC
Protein S Serum High Needed   ISTH
Protein, total Urine Low Inactive    
Protein, total Serum Medium Adequate/Maintain    
Pseudocholinesterase Serum Low Adequate/Maintain    
Quinidine Serum/ plasma Low Inactive    
Rheumatoid factor (RF) Serum Low Needed    
Rotavirus Ag Stool High Adequate/Maintain    
Sirolimus Blood High Active JCTLM
Sodium Serum High Adequate/Maintain JCTLM
Syphilis Serum High Adequate/Maintain See Treponema pallidum
Tacrolimus Blood High Active JCTLM
IFCC Working Group on Immunosuppressive Drugs
Theophylline Serum, heparin plasma Medium Adequate/Maintain JCTLM
Theophylline Serum, Plasma Medium Adequate/Maintain JCTLM
Thyroid stimulating hormone (TSH) Serum High Active   IFCC
Thyroxine (T4) Serum High Active JCTLM
Thyroxine, free (FT4) Serum High Active   IFCC
Tobramycin Serum/plasma Medium Adequate/Maintain    
Toxoplasma gondii IgG Serum High Adequate/Maintain    
Transferrin Serum Medium Adequate/Maintain JCTLM
Treponema pallidum Antibodies Serum High Adequate/Maintain WHO International Standard 1st IS for human syphilitic plasma IgG and IgM, code: 05/132
Triglycerides Serum High Adequate/Maintain JCTLM
Triiodothyronine, free (FT3) Serum High Needed    
Troponin I, cardiac (cTnI) Serum High Active JCTLM
Troponin T Serum High Adequate/Maintain    
Urea N (BUN) Serum Medium Adequate/Maintain JCTLM
Uric acid Serum Medium Adequate/Maintain JCTLM
Valproic Acid Serum, Plasma Medium Adequate/Maintain    
Vancomycin Serum Medium Needed JCTLM
Vitamin B12 Serum Medium Incomplete    
Vitamin D Serum Medium Active JCTLM
National Institutes of Health, USA
Centers for Disease Control, USA