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Measurands

This table provides information on the status of harmonization or standardization of measurands. Additional information regarding the medical impact and harmonization status is available by clicking on the measurand name. The harmonization status shown in the table reflects the situation in economically well developed countries and other geographic areas when measurement procedures supplied by global IVD manufactures are used. The harmonization status may be different when reagents, calibrators and instruments from other suppliers are used.


The medical impact of harmonization, or priority for harmonization, is based on the influence of non-harmonized results on potential medical errors when interpreting a result for a measurand.

Harmonization status:

  • Active means an organization is implementing a harmonization project.
  • Adequate/Maintain means the current harmonization is suitable for medical decisions and existing reference systems must be maintained to ensure the status remains adequate.
  • Inactive means a harmonization activity was started, is no longer being actively implemented but should be reinstated.
  • Incomplete means resources to achieve harmonization are available but have not been adequately implemented.
  • Needed means no harmonization activity has been started but one is needed.

The Resources column notes when information on reference materials, reference measurement procedures, and reference laboratory services are listed by JCTLM.

The Organization column provides information on organizations actively addressing harmonization or standardization for the measurand, or developing reference materials or reference measurement procedures for the measurand.

Comments on measurand status can be sent using the Contact Us tab. Download the form to submit a new measurand.


Summary of Measurand Harmonization Activities

The measurand table is a dynamic information resource. Check regularly for new information.

Click on a measurand to see additional information regarding harmonization status and medical impact.

Click on a link (blue text) for information on a resource or organization.

Click on a single column to sort the table.

Measurand Matrix Medical Impact of Harmonization Harmonization Status Resources Organization
Alanine Aminotransferase (ALT) Serum Medium Incomplete JCTLM IFCC
Albumin Serum Medium Needed JCTLM IFCC
Albumin Urine High Active JCTLM IFCC
Alkaline Phosphatase (ALP) Serum Medium Incomplete JCTLM IFCC
Alpha Fetoprotein Serum High Adequate/Maintain JCTLM IFCC
Amylase Serum Low Active JCTLM IFCC
Anti-DNA antibody (qualitative) Serum Low JCTLM IFCC
Anti-DNA antibody (quantitative) Serum Medium Needed JCTLM IFCC
Anti-HBs Qualitative Serum, Plasma High Adequate/Maintain JCTLM IFCC
Anti-HBs Quantitative Serum, Plasma Medium Needed JCTLM IFCC
Anti-Hepatitis B core (Anti-HBc total IgM and IgG) Serum, plasma High Adequate/Maintain JCTLM IFCC
Anti-Hepatitis B Surface Antigen (Anti-HBsAg) Serum, Heparin Plasma High Needed JCTLM IFCC
Anti-Hepatitis C Virus antibody (Anti-HCV Ab) Serum Medium Adequate/Maintain JCTLM IFCC
Anti-myeloperoxidase (MPO) antibody, IgG Serum High Needed JCTLM IFCC
Anti-SSA antibody IgG Serum Medium Needed JCTLM IFCC
Antinuclear antibody (ANA) fixed cells or serum Active JCTLM IFCC
Antistreptolysin O Serum Low Needed JCTLM IFCC
Aspartate Aminotransferase (AST) Serum Medium Incomplete JCTLM IFCC
B-type Natriuretic Peptide (BNP) Serum High Needed JCTLM IFCC
BCR-ABL1 Whole blood, bone marrow High Adequate/Maintain JCTLM IFCC
Bilirubin, conjugated Serum Medium Needed JCTLM IFCC
Bilirubin, total Serum High Adequate/Maintain JCTLM IFCC
Blood gasses (pH, pO2, pCO2, oximitry) Blood High Adequate/Maintain JCTLM IFCC
C-Peptide Serum Medium Active JCTLM IFCC
C-Reactive protein, high sensitivity Serum Medium Adequate/Maintain JCTLM IFCC
C-Reactive protein, inflammatory Serum Low Incomplete JCTLM IFCC
CA 125 Serum High Needed JCTLM IFCC
CA 15-3 Serum High Needed JCTLM IFCC
CA 19-9 Serum High Needed JCTLM IFCC
Calcium Serum High Adequate/Maintain JCTLM IFCC
Calcium, ionized Blood Medium Needed JCTLM IFCC
Carbamazepine Serum Medium Adequate/Maintain JCTLM IFCC
Carbohydrate-deficient transferin (CDT) Serum Medium Active JCTLM IFCC
Carboxyhemoglobin Blood Medium Adequate/Maintain JCTLM IFCC
Carcinoembrionic antigen (CEA) Serum High Needed JCTLM IFCC
Chlamydia Trachomatis PCR Urine, Vaginal Swab High Adequate/Maintain JCTLM IFCC
Chloride Serum High Adequate/Maintain JCTLM IFCC
Cholesterol, HDL Serum High Incomplete JCTLM IFCC
Cholesterol, LDL Serum Medium Incomplete JCTLM IFCC
Cholesterol, total Serum High Adequate/Maintain JCTLM IFCC
CO2, Total Serum, Heparin Plasma Medium Needed JCTLM IFCC
Complement Total (CH50) Serum Medium Needed JCTLM IFCC
Compliment C3 Serum Medium Active JCTLM IFCC
Compliment C4 Serum Medium Active JCTLM IFCC
Cortisol Serum Medium Incomplete JCTLM IFCC
Creatine Kinase (CK) Serum Medium Incomplete JCTLM IFCC
Creatinine Serum High Adequate/Maintain JCTLM IFCC
CSF Proteins CSF Medium Active JCTLM IFCC
Cyclosporin Blood High Active JCTLM IFCC
Cytomegalovirus (CMV) Plasma Medium Needed JCTLM IFCC
Cytomegalovirus IgG (CMV IgG) Serum Medium Adequate/Maintain JCTLM IFCC
D-dimer plasma High Needed JCTLM IFCC
Digoxin Serum Medium Needed JCTLM IFCC
Elastase I Fecal, Serum Low Unknown JCTLM IFCC
Epstein-Barr Virus Blood Medium Active JCTLM IFCC
Estradiol (17-beta) Serum High Active JCTLM IFCC
Ethyl Alcohol Serum, Plasma Medium Adequate/Maintain JCTLM IFCC
Ferritin Serum, Plasma Medium Adequate/Maintain JCTLM IFCC
Fetal fibronectin Cervical fluid Low Unknown JCTLM IFCC
Fibrin Degradation Products (D-dimer) plasma High Needed JCTLM IFCC
Folate Serum Medium Needed JCTLM IFCC
Fructosamine Serum Low Adequate/Maintain JCTLM IFCC
Gamma glutamyl transferase (GGT) Serum Medium Adequate/Maintain JCTLM IFCC
Gentamicin Serum/plasma Medium Adequate/Maintain JCTLM IFCC
Glucose Serum High Adequate/Maintain JCTLM IFCC
Glucose Urine Low Adequate/Maintain JCTLM IFCC
Glucose (POCT) Blood High Adequate/Maintain JCTLM IFCC
Glycated Albumin Serum Medium Adequate/Maintain JCTLM IFCC
Growth Hormone Serum High Active JCTLM IFCC
Hematocrit Blood High Adequate/Maintain JCTLM IFCC
Hemoglobin Blood High Adequate/Maintain JCTLM IFCC
Hemoglobin A1c (HbA1c) Blood High Adequate/Maintain JCTLM IFCC
Hemoglobin A2 (HbA2) Serum Medium Active JCTLM IFCC
Hemoglobin, fetal (HbF) Blood Low Adequate/Maintain JCTLM IFCC
Hepatitis B Surface Antigen (HBsAg) Serum, Heparin Plasma High Adequate/Maintain JCTLM IFCC
Hepatitis C Ab qualitative Serum, Plasma High Adequate/Maintain JCTLM IFCC
Hepatitis C Virus RNA Serum High Adequate/Maintain JCTLM IFCC
HIV-1 Genotype Plasma, Dried blood spots High Adequate/Maintain JCTLM IFCC
HIV-RNA Serum, Plasma High Adequate/Maintain JCTLM IFCC
Human Chorionic Gonadotropin (hCG) Serum High Needed JCTLM IFCC
IgA, total Serum Medium Adequate/Maintain JCTLM IFCC
IgE, total Serum Medium Adequate/Maintain JCTLM IFCC
IgG, Total Serum Medium Adequate/Maintain JCTLM IFCC
IgM, total Serum Medium Adequate/Maintain JCTLM IFCC
Insulin Serum Medium Active JCTLM IFCC
Iron Serum Medium Adequate/Maintain JCTLM IFCC
Iron Binding Capacity (Total): TIBC Serum Low Adequate/Maintain JCTLM IFCC
Iron binding capacity (unsaturated ) Serum Low Adequate/Maintain JCTLM IFCC
Iron saturation Serum Low Adequate/Maintain JCTLM IFCC
Lactate Serum High Adequate/Maintain JCTLM IFCC
Lactate Dehydrogenase (LDH) Serum Medium Incomplete JCTLM IFCC
Lipase Serum Medium Active JCTLM IFCC
Lithium Serum, Heparin Plasma High Adequate/Maintain JCTLM IFCC
Lp (a) serum/ plasma High Active JCTLM IFCC
Magnesium Serum High Adequate/Maintain JCTLM IFCC
Methemoglobin Blood Low Inactive JCTLM IFCC
Methotrexate Serum Low Adequate JCTLM IFCC
Myoglobin Serum, Urine Low Adequate/Maintain JCTLM IFCC
Neisseria gonorrhea DNA by PCR Urine, Vaginal Swab High Adequate/Maintain JCTLM IFCC
Osmolality Serum Medium Adequate/Maintain JCTLM IFCC
Osmolality Urine Medium Adequate/Maintain JCTLM IFCC
Oxyhemoglobin Blood Medium Adequate/Maintain JCTLM IFCC
Pancreatic lipase Serum Medium Active JCTLM IFCC
Parathyroid hormone (PTH) Serum High Active JCTLM IFCC
Phenobarbital Serum, Plasma Medium Adequate/Maintain JCTLM IFCC
Phenytoin Serum Medium Adequate/Maintain JCTLM IFCC
Phosphate Serum Medium Adequate/Maintain JCTLM IFCC
Platelet Count Blood High Needed JCTLM IFCC
Potassium Serum High Adequate/Maintain JCTLM IFCC
Pregnancy-Associated Plasma Protein A Plasma Active JCTLM IFCC
Procalcitonin Serum High Needed JCTLM IFCC
Prostate Specific Antigen (PSA) Serum High Needed JCTLM IFCC
Protein in CSF CSF Low Active JCTLM IFCC
Protein S Serum High Needed JCTLM IFCC
Protein, total Urine Low Inactive JCTLM IFCC
Protein, total Serum Medium Adequate/Maintain JCTLM IFCC
Pseudocholinesterase Serum Low Adequate/Maintain JCTLM IFCC
Quinidine Serum/ plasma Low Inactive JCTLM IFCC
Rheumatoid factor (RF) Serum Low Needed JCTLM IFCC
Rotavirus Ag Stool High Adequate/Maintain JCTLM IFCC
Sirolimus Blood High Active JCTLM IFCC
Sodium Serum High Adequate/Maintain JCTLM IFCC
Syphilis Serum High Adequate/Maintain JCTLM IFCC
Tacrolimus Blood High Active JCTLM IFCC
Theophylline Serum, heparin plasma Medium Adequate/Maintain JCTLM IFCC
Theophylline Serum, Plasma Medium Adequate/Maintain JCTLM IFCC
Thyroid stimulating hormone (TSH) Serum High Active JCTLM IFCC
Thyroxine (T4) Serum High Active JCTLM IFCC
Thyroxine, free (FT4) Serum High Active JCTLM IFCC
Tobramycin Serum/plasma Medium Adequate/Maintain JCTLM IFCC
Toxoplasma gondii IgG Serum High Adequate/Maintain JCTLM IFCC
Transferrin Serum Medium Adequate/Maintain JCTLM IFCC
Treponema pallidum Antibodies Serum High Adequate/Maintain JCTLM IFCC
Triglycerides Serum High Adequate/Maintain JCTLM IFCC
Triiodothyronine, free (FT3) Serum High Needed JCTLM IFCC
Troponin I, cardiac (cTnI) Serum High Active JCTLM IFCC
Troponin T Serum High Adequate/Maintain JCTLM IFCC
Urea N (BUN) Serum Medium Adequate/Maintain JCTLM IFCC
Uric acid Serum Medium Adequate/Maintain JCTLM IFCC
Valproic Acid Serum, Plasma Medium Adequate/Maintain JCTLM IFCC
Vancomycin Serum Medium Needed JCTLM IFCC
Vitamin B12 Serum Medium Incomplete JCTLM IFCC
Vitamin D Serum Medium Active JCTLM IFCC